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Title: 動物性蛋白摂取の尿中結石形成因子におよぼす影響に関する研究
Other Titles: Studies of influence of animal protein intake on the urinary risk factors of calcium oxalate stone formation
Authors: 西井, 正治  KAKEN_name
Author's alias: NISHII, Masaharu
Keywords: Calcium oxalate stone
Animal protein
Risk factor
Issue Date: Dec-1984
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 30
Issue: 12
Start page: 1737
End page: 1747
Abstract: 1)結石患者および健常者での動物性蛋白負荷(61 g/day)による尿中risk factorの変動に関し検討した.1)尿中Ca排泄量は負荷により両群とも27%と有意に増加した.2)尿中Ox排泄量は負荷後,結石群では4日目に,健常群では3, 4日目に減少傾向を示し,低Ox食の状態であり,この変動は主として尿中内因性Oxによると考えた.3)尿中尿酸排泄量は負荷により結石群43%,健常群58%と有意に増加した.4)尿中AGAG, Mg排泄量には負荷により,一定の変動は認めなかった.2)ラットの動物性蛋白負荷による尿中Ca, Ox排泄量の変化に関し検討した.1)尿中Ca排泄量は負荷により高Ox低Ca食,低Ox高Ca食,高Ox高Ca食の3群ではそれぞれ112%,119%,92%と排泄増加した.Ca摂取量の多寡にかかわらず動物性蛋白負荷は尿中Ca排泄を増加した.2)尿中Ox排泄量は低Ox高Ca食,高Ox高Ca食では負荷により増加しなかったが,高Ox低Ca食では負荷により41%とOx排泄増加を示した.吸収しうるOxが多いときのみ動物性蛋白負荷による尿中Ox排泄は増加すると考えられ,動物性蛋白負荷はOxの腸管からの吸収の亢進を示唆した
To examine the effects of excessive animal protein intake on the urinary risk factors of calcium oxalate stone formation, protein loading experiments were performed on oxalate stone formers and normal subjects and rats. By animal protein loading of 61 g/day with diet which contained 400 mg of calcium and 46.6 mg of total oxalate, urinary calcium excretion increased by 27% both in stone formers and in normal subjects. Urinary oxalate excretion had a tendency to decrease on the 3rd and 4th days after loading. Urinary uric acid excretion increased significantly after loading. No significant change was recognized in the acid glycosaminoglycan (AGAG) and magnesium excretion. Urinary calcium excretion increased both in the high and low calcium diet groups after animal protein loading in the rat experiment. Urinary oxalate excretion increased after loading only in high oxalate low calcium diet group, therefore, it was supposed that animal protein intake caused increase of intestinal oxalate absorption.
URI: http://hdl.handle.net/2433/118365
PubMed ID: 6532203
Appears in Collections:Vol.30 No.12

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