前立腺癌患者血清中γ-セミノプロティン

Abstract

1)未治療前立腺癌51例でγ-Smは, PAP-RIAに比し, stage B, Cでの陽性率が高く, 早期診断に有用と考えた.2)治療後4週で74%の例でγ-Smが陰性となった.3)制癌例に比べて, 再燃例で有意にγ-Smの陽性の割合が大きかった(p<0.01).再燃の診断の一助となる

From August, 1981 to May, 1984, we measured gamma-seminoprotein in the serum of 51 untreated patients with prostatic cancer in the Chiba University Hospital. Prostatic acid phosphatase (radioimmunoassay) in serum was also measured in these patients. We also measured gamma-seminoprotein and prostatic acid phosphatase in serum of patients under control by hormonal treatment and of reactivated patients. In untreated stage B and stage C cases, positive rate of gamma-seminoprotein in serum was larger than that of prostatic acid phosphatase. Therefore the measurement of gamma-seminoprotein in serum is considered to be useful in the diagnosis of early prostatic cancer. Four weeks after hormonal treatment, gamma-seminoprotein in the serum of 74% of the patients returned to the normal level. The positive rate of gamma-seminoprotein in the serum of reactivated patients is significantly larger than that of the patients under control by hormonal therapy.