尿路結石患者に見出された高カルシウム尿の治療

Abstract

尿路結石症の既往のある高Ca尿35例に対し, Hydrochlorothiazide 50 mg/dayを投与した.1)投与前に比し, 投与4週後の尿中Ca排泄量は有意に低下した.この低下は3ヵ月, 6ヵ月後も持続した.尿中Mg量には差がなかったが, Mg:Ca比は上昇した.尿量には変化がなかった.2)血中尿酸値は上昇したが, 尿中尿酸値には差を認めなかった.3)血中K値は本剤により低下した.4)本剤投与による重篤な副作用はみられなかった

To reduce urinary calcium excretion, 50 mg of hydrochlorothiazide per day was given to 35 patients with hypercalciuria. Urinary calcium decreased significantly after 4 weeks of drug administration, but urinary magnesium did not change. Magnesium calcium ratio increased significantly. Although serious side effects were not seen, serum potassium decreased and serum uric acid increased significantly. From these results thiazide seems to be a useful and safe medicine to reduce urinary calcium excretion. The dose and method of administration require further examination because the patients have to take the drug for a long time.