オリーブ橋小脳萎縮症による神経因性膀胱に対するThyrotropin Releasing Hormoneの使用経験

Abstract

The effect of thyrotropin-releasing hormone (TRH) on vesicourethral dysfunction in two patients with olivo-ponto-cerebellar atrophy was studied by urodynamic examination. The two patients had difficulty of urination with 200 ml of residual urine. Cystometrogram and electromyogram showed autonomous contraction without detrusor-sphincter dyssynergia. After administration of TRH, the symptom and volume of residual urine was not improved, autonomous contraction was not changed, while prostatic urethral pressure in urethral pressure profile was significantly increased in both patients.