Therapeutic experience of advanced urothelial tract tumors

Abstract

23例の進行性尿路上皮腫瘍に対し, 外科療法, 化学療法, 放射線療法をおこなった.放射線療法の有無にかかわらず, 根治的外科手術により8例がtumor freeになった.15例に対する化学療法で1例が, CR, 5例がPRとなった.low grade, low stage, Karnofsky performance ratingが高い例に対しては高成績が得られた.CDDP, ADM, cyclophosphamideの三者併用療法, またはCDDP中心の化学療法は進行性尿路上皮腫瘍に対して有効であると推測された

Twenty-three patients with locally advanced and/or metastatic urothelial tumors were treated by surgery, chemotherapy or radiation. Radical operation with or without radiation resulted in tumor free conditions in 8 patients. Fifteen patients who had a few dimensionally estimable disease parameters, underwent chemotherapy. Objective responses were obtained in 6 of the 15 patients (1 CR and 5 PR). The objective response of low grade or low stage tumors or cases with high Karnofsky performance ratings was moderate. Combination chemotherapy with cisplatin (CDDP), doxorubicin (ADM) and cyclophosphamide or a CDDP-containing combination appeared to be beneficial for patients with advanced urothelial tract tumors with palliative purpose.