前立腺肥大症に対するLisuride hydrogen maleate (SH-1072)の臨床効果 : 治療成績と作用機作に関する考察

Abstract

軽症～中等症前立腺肥大症12例に, ドーパミン作働薬LHM 75～150 μg/日を投与し, 排尿状態, 夜間排尿回数などの評価項目で有意な症状の改善をみた.投与後血中プロラクチン値は低下したが, 本剤の臨床効果は, このほかに, 本剤の抗αアドレナリン作用に由来するであろうと, 文献上からも示唆した

Lisuride hydrogen maleate (LHM, SH-1072), a dopaminergic agonist and therefore an inhibitor of prolactin (PRL) secretion, were administered to 12 patients with mild to moderate BPH in order to evaluate the clinical effectiveness. LHM was administered 75 or 150 mcg/day, po, for 20 weeks on the average. The status of micturition evaluated by score points and nocturnal frequency of urination was significantly improved, whereas objective responses such as on the amount of residual urine, size of the prostate gland, findings of urethrocystography and the length of prostatic urethra measured on the film were minimal. Serum PRL level have been reduced significantly through the therapy, and testosterone were unchanged. The mechanism of action of the agent on BPH and the surrounding tissue was discussed; reduced androgen effect on the prostate through lowering of PRL and anti-alpha-adrenergic activity or the effect through prostaglandin on the gland, the bladder neck and the posterior urethra would mitigate the symptoms.