膀胱移行上皮癌に対するペプロマイシン加膀胱内灌流温熱療法

Abstract

20例の膀胱癌症例に対し, ペプロマイシン灌流による温熱療法を施行し, 腫瘍の完全消失1例を含む, 計8例に25%以上の腫瘍の縮小が得られた

Hyperthermic intravesical perfusion therapy using peplomycin (40 micrograms/ml) in distilled water at 43 degrees C as a perfusate was performed for 2 to 3 hours in 18 patients with superficial bladder tumors and 2 with deep bladder tumors. The therapeutic efficacy was determined by cystoscopy, ultrasonography and/or CT scan. Complete and partial tumor regression was obtained in 1 and 3 of the 18 patients, respectively. There was no tumor regression in the 12 patients. Most of the patients studied had bladder discomfort such as irritation, urinary frequency and so on, during and/or after perfusion. None of the patients developed acute pyelonephritis.