膀胱癌組織中carcinoembryonic antigenと血液型抗原の検討

Abstract

膀胱腫瘍47例に対し, peroxidase antiperoxydase法により組織内carcinoembryonic antigen (CEA)を, またAvidin-biotin-peroxidase complex法により血液型抗原を同時に検索した.1)膀胱組織内CEA陽性例は12例25.3%であり, 一方血液型抗原の陽性例は30例63.8%であった.2)組織内CEAおよび血液型抗原の存在は膀胱腫瘍の進展度および悪性度を反映した.3)血液型抗原陰性例におけるCEA陽性率は67.7%, 血液型抗原陽性例におけるCEA陽性率は3.3%であり, 両者おのおのの存在は相反する関係にあるものと考えられた.4)組織内CEAおよび血液型抗原の検索はともに病理組織診断の手助けとなるものと考えられる

The carcinoembryonic antigen (CEA) and ABO (H) blood group antigens of 47 bladder tumors were investigated by immunohistochemistry (CEA by peroxidase-antiperoxidase method and blood group antigens by Avidin-biotin-peroxidase complex method) and the results were compared with the histopathological diagnosis. Twenty five percent of the bladder tumors had CEA-positive tumor cells. They were found in 11.1% of pT1 cases, in 12.5% of pT2 cases, 70.0% of pT3 cases and 50.0% of pT4 cases and were also found in 13.3% of grade I cases, in 50.0% of grade II cases and in 40.0% of grade III cases. On the other hand, positive blood group antigen cells were found in 85.2% of pT1 cases, 50.0% of pT2 cases, 20.0% of pT3 cases and 50.0% of the pT4 cases and also in 80.0% of the grade I cases, 41.1% of the grade II cases, and 20.0% of the grade III cases. A statistical difference was seen between the low stage (pT1) and high stage cases (pT2-pT4) and between the low grade (G-I) and high grade cases (G-II, III) (P less than 0.01) for both CEA and the blood group antigens which were statistically related (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)