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dc.contributor.author | 熊本, 悦明 | ja |
dc.contributor.author | 酒井, 茂 | ja |
dc.contributor.author | 玉手, 広時 | ja |
dc.contributor.author | 郷路, 勉 | ja |
dc.contributor.author | 猪野毛, 健男 | ja |
dc.contributor.author | 田端, 重男 | ja |
dc.contributor.author | 丹田, 均 | ja |
dc.contributor.author | 加藤, 修爾 | ja |
dc.contributor.author | 井川, 欣市 | ja |
dc.contributor.author | 田付, 二郎 | ja |
dc.contributor.author | 辺見, 泉 | ja |
dc.contributor.author | 生垣, 舜二 | ja |
dc.contributor.author | 吉尾, 弘 | ja |
dc.contributor.author | 上野, 了 | ja |
dc.contributor.author | 出口, 浩一 | ja |
dc.contributor.alternative | KUMAMOTO, Yoshiaki | en |
dc.contributor.alternative | SAKAI, Shigeru | en |
dc.contributor.alternative | TAMATE, Hirotoki | en |
dc.contributor.alternative | GOHRO, Tsutomu | en |
dc.contributor.alternative | INOKE, Takeo | en |
dc.contributor.alternative | TABATA, Shigeo | en |
dc.contributor.alternative | TANDA, Hitoshi | en |
dc.contributor.alternative | KATO, Shuji | en |
dc.contributor.alternative | IGAWA, Kinichi | en |
dc.contributor.alternative | TAZUKI, Jiro | en |
dc.contributor.alternative | HENMI, Izumi | en |
dc.contributor.alternative | IKEGAKI, Shunji | en |
dc.contributor.alternative | YOSHIO, Hiroshi | en |
dc.contributor.alternative | UENO, Tooru | en |
dc.contributor.alternative | DEGUCHI, Kohichi | en |
dc.date.accessioned | 2010-06-02T02:05:11Z | - |
dc.date.available | 2010-06-02T02:05:11Z | - |
dc.date.issued | 1985-11 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/118646 | - |
dc.description.abstract | 淋菌性感染症244例(男子尿道炎212例, 女子子宮頸管炎32例)に対し, Aztreonam one shot (1~2 g)治療を試みた.1)症例より分離した淋菌244株中42株(17.2%)がPPNGであった.2) Aztreonamの淋菌に対する106 CFU/mlでのMICはβ-lactamase産生に関係なく, 0.025 μg/mlにpeakをもち, 0.0125 μg/ml以下から0.2 μg/mlに分布していた.3) Aztreonam 1 gおよび2 g投与による淋菌の消失時間は1~8時間, 平均4~4.5時間の間に消失をみており, 1 gと2 gの間にほとんど差は認められなかった.4) Aztreonam 1 g one shot, 2 g one shotによる臨床効果を男女244例について検討したが, 3日所見で判定するとPPNGでも治療効果は変らず, 有効率は男子尿道炎では1 g 90.7%, 2 g 97.1%, 女子子宮頸管炎では1 g, 2 gとも100%であった.5) Aztreonamの副作用は244例中しびれ, 両手に発赤, 腫脹1例, 倦怠感1例の計2例(0.8%)にみられたがいずれも軽度であった | ja |
dc.description.abstract | A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49.5%, female 43.7%) and the percent of teen age patients was 15.1% (male) and 34.4% (female). Forty two strains (17.2%) out of 244 clinically isolated gonococci were PPNG. Residue of serious secretion was observed in a little less than 20% suggesting a complication by Chlamydia trachomatis. Clinical Result: One shot (1-2 g) therapy by AZT was given to 244 gonorrheal infection cases (212 urethritis cases of males. 32 cervicitis cases of females) with the following highly effective rate. Although beta-lactamase producing MIC of AZT at 10(6) CFU/ml showed a peak of 0.025 microgram/ml and ranged between less than 0.0125 microgram/ml to 0.2 microgram/ml. The time required for the elimination of gonococci was studied by the administration of 1 g and 2 g AZT. Gonococci became extinct in 1-8 hours or 4-4.5 hours on average. The difference between n 1 g and 2 g was scarcely observed. Clinical effect of 1 g one shot and 2 g one shot AZT was examined on the 3rd treatment day for 244 male and females cases. The effective rate was high; 90.7% by 1 g, 97.1% by 2 g for male urethritis, 100% by 1 g also by 2 g for female cervicitis. This therapeutic efficacy was kept even in PPNG, isolated cases. There were two side effects (0.8%), one case each of numbness and, redness and swelling of both hands, out of 244 cases, but both of them were minor ones without clinical complication. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | STD | en |
dc.subject | Gonorrheal infections | en |
dc.subject | Aztreonam | en |
dc.subject | One shot therapy | en |
dc.subject.ndc | 494.9 | - |
dc.title | 淋菌性感染症の疫学的治療学的研究 --Aztreonamによるone shot療法の検討-- | ja |
dc.title.alternative | Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 2090 | - |
dc.identifier.epage | 2104 | - |
dc.textversion | publisher | - |
dc.sortkey | 27 | - |
dc.address | 札幌医科大学泌尿器科学教室 | ja |
dc.address | 札幌医科大学泌尿器科学教室 | ja |
dc.address | 玉手皮膚泌尿器科医院 | ja |
dc.address | 札幌泌尿器科医院 | ja |
dc.address | いのけ医院皮膚泌尿器科 | ja |
dc.address | 田端皮膚泌尿器科医院 | ja |
dc.address | 東札幌三樹会病院泌尿器科 | ja |
dc.address | 東札幌三樹会病院泌尿器科 | ja |
dc.address | 陸上自衛隊札幌地区病院泌尿器科 | ja |
dc.address | 陸上自衛隊札幌地区病院泌尿器科 | ja |
dc.address | 辺見医院皮膚泌尿器科 | ja |
dc.address | いけがき皮膚泌尿器科医院 | ja |
dc.address | 吉尾病院産婦人科 | ja |
dc.address | 第一臨床検査センター | ja |
dc.address | 東京総合臨床検査センター | ja |
dc.address.alternative | the Depatment of Urology, Sapporo Medical College | en |
dc.address.alternative | the Tamate Clinic | en |
dc.address.alternative | the Sapporo Urology Clinic | en |
dc.address.alternative | the Inoke Clinic | en |
dc.address.alternative | the Tabata Clinic | en |
dc.address.alternative | the Higashi Sapporo Sanjukai Hospital | en |
dc.address.alternative | the Higashi Sapporo Sanjukai Hospital | en |
dc.address.alternative | the Depatment of Urology, Self- Defens Feorce Sapporo Hospital | en |
dc.address.alternative | the Depatment of Urology, Self- Defens Feorce Sapporo Hospital | en |
dc.address.alternative | the Henmi Clinic | en |
dc.address.alternative | the Ikegaki Clinic | en |
dc.address.alternative | the Yoshio Clinic | en |
dc.address.alternative | the Daiichi Clinical Research Center | en |
dc.address.alternative | the Tokyo Clinical Research Center | en |
dc.identifier.pmid | 3937450 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.31 No.11 |
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