尿路感染症に対するNorfloxacinの臨床的検討

Abstract

尿路感染症症例34例にNorfloxacinを投与した結果を報告した.UTI薬効評価基準にもとづいて総合臨床効果を判定した単純性尿路感染症13例, 複雑性尿路感染症10例の有効率はそれぞれ100%, 82.4%と満足できる成績であった.細菌学的効果も, 菌消失率が96.2%と良好な結果が得られた.副作用もほとんどなく, GOT, GPTの一過性軽度上昇が1例にのみ認められた

The clinical effectiveness and safety of norfloxacin were evaluated in 34 patients with urinary tract infections. Out of 13 patients with simple UTI evaluated by the UTI criteria, the results were excellent in 12 cases (92.3%) and moderate in 1 case (7.7%). For complicated UTI evaluated by the UTI criteria, the results were excellent in 7 cases (70%), moderate in 2 cases (20%) and poor in 1 case (10%). The clinical efficacy was satisfactory in the cases of 2 complicated urinary tract infections as well as simple urinary tract infection. Out of 26 strains of bacteria isolated before treatment, 25 strains (96.2%) were eradicated after treatment. There were no remarkable adverse effects. Only one patient showed slight elevation of serum transaminase transiently. From the above results, norfloxacin is considered to be useful and safe in the treatment of urinary tract infection.