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タイトル: | 前立腺癌に対する(D-Leu6)-des Gly-NH210-LH・RH ethylamide (Leuprolide)の臨床効果 --とくに少量投与時における血中ホルモンに対する影響-- |
その他のタイトル: | Hormonal and clinical efficacy of (D-Leu6)-des Gly-NH2(10)-LH.RH ethylamide against prostatic cancer |
著者: | 今井, 強一 熊坂, 文成 小林, 幹男 鈴木, 孝憲 高橋, 修 山中, 英寿 |
著者名の別形: | Imai, Kyoichi Kumasaka, Fuminari Kobayashi, Mikio Suzuki, Takanori Takahashi, Osamu Yamanaka, Hidetoshi |
キーワード: | Aged Antineoplastic Agents/administration & dosage/therapeutic use Dehydroepiandrosterone/blood Drug Administration Schedule Estradiol/blood Follicle Stimulating Hormone/blood Gonadotropin-Releasing Hormone/administration & dosage/analogs & derivatives/therapeutic use Humans Injections, Subcutaneous Leuprolide Luteinizing Hormone/blood Male Middle Aged Prostatic Neoplasms/blood/drug therapy Testosterone/blood |
発行日: | Dec-1985 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 31 |
号: | 12 |
開始ページ: | 2302 |
終了ページ: | 2306 |
抄録: | 1) TAP 144 1 mg/day連日皮下投与は20 mg/day投与と比較しても, LH, FSH, T.などの血中ホルモンにたいする作用は変らなかった.2) 7例の前立腺癌症例に対してTAP 144 1 mg/day連日皮下投与によって, PR 4例・stable 3例であった.3) TAP 144 1 mg/day 12症例に使用して, あきらかな副作用は認められなかった The hormonal and clinical efficacy of (D-Leu6)-des Gly-NH2(10)-LH.RH ethylamide (Leuprolide, TAP 144) was investigated with 12 prostatic cancer patients. The hormonal studies were performed in 8 patients who were not previously treated by any hormonal therapies including estrogen, castration and others. Serum level of LH and FSH was apparently decreased at the end of 2 weeks after the starting of leuprolide (1 mg/day) subcutaneous injection. At the same time, testosterone level was decreased to the castration level. Clinical efficacy of 1 mg/day of leuprolide was evaluated in 7 patients who were not previously treated. Three of the 4 patients with stage B2 cancer showed a partial response and 1 patient a stable response; and 1 of the 3 patients with stage D2 cancer showed a partial response and patients stable a response. No significant side effects were observed in these 12 patients. These results show that 1 mg/day of leuprolide has the same degree of potency in decreasing the serum testosterone as 20 mg/day. |
URI: | http://hdl.handle.net/2433/118676 |
PubMed ID: | 2938456 |
出現コレクション: | Vol.31 No.12 |
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