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Title: 副甲状腺の内分泌代謝に関する研究 2: 副腎皮質刺激ホルモン(ACTH)がカルシウム代謝と副甲状腺機能におよぼす影響
Other Titles: Studies on the endocrinological metabolism of the parathyroid. II. Influence of ACTH on parathyroid function and calcium metabolism
Authors: 郡, 健二郎  KAKEN_name
高田, 昌彦  KAKEN_name
加藤, 良成  KAKEN_name
片岡, 喜代徳  KAKEN_name
井口, 正典  KAKEN_name
栗田, 孝  KAKEN_name
八竹, 直  KAKEN_name
Author's alias: Kohri, Kenjiro
Takada, Masahiko
Katoh, Yoshinari
Kataoka, Kiyonori
Iguchi, Masanori
Kurita, Takashi
Yachiku, Sunao
Keywords: Adrenocorticotropic Hormone/pharmacology/physiology
Middle Aged
Parathyroid Glands/physiology
Parathyroid Hormone/physiology
Receptors, Cell Surface/physiology
Receptors, Parathyroid Hormone
Urinary Calculi/metabolism
Issue Date: Dec-1985
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 31
Issue: 12
Start page: 2149
End page: 2159
Abstract: 副甲状腺ホルモン(以下PTH)にも上位ホルモンが存在しないものかと考え,Ca代謝となんらかの関連性があり,かつ代表的な上位ホルモンである副腎皮質ホルモン(ACTH)を原発性副甲状腺機能亢進症など4群の疾患に投与したところ,興味ある結果を得たので,in vitroやラットを用いて実験を行った.対象は,副甲状腺摘除術を施行した原発性副甲状腺機能亢進症17例,Ca含有上部尿路結石患者7例,血清Ca値が11 mg/dl以上の高Ca血症を伴う悪性腫瘍患者7例と,正常対照群6例である.ACTH投与後の血清Caは,原発性副甲状腺機能亢進症では有意の上昇をみたが,他の群では変化がなかった.血清Caの上昇の割合はACTH投与前の血清Ca値と正の相関があり,投与前の血清ALP値と負の相関があった.ACTH投与前後のコルチゾール値やACTH値は4群間に差異がなかった.副甲状腺機能亢進症ではACTHの投与後,PTHが上昇傾向にあったが血清P,尿中Ca, Pは変化がなかった.摘除副甲状腺腺腫の培養液にACTHを添加したところ,PTH濃度は上昇傾向にあった.副甲状腺摘除ラットではACTH投与後血清Caは有意に低下し,副腎摘除ラットでは血清Caは有意に上昇した.以上からACTHにはコルチゾールを介すると思われる血清Ca低下作用の他に2つの機序による血清Ca上昇作用があることが考えられる.1つはACTHが直接刺激し,PTHの分泌による機序で,あと1つは骨に存在するPTHレセプターのうち,不活性レセプターに存在するPTHが,PTHと競合作用を持つACTHにより活性レセプターに移行するため骨吸収が生じる機序が文献的に推察された.ACTH投与にても高Ca血症を伴う悪性腫瘍患者では血清Caの上昇がみられなかったことから,高Ca血症の鑑別診断に役立つものと思われた
Parathyroid hormone (PTH) is strongly concerned with the pathogenesis of urinary stones. PTH is mainly regulated by the serum calcium concentration and not by other hormones, as is usually the case. We studied whether PTH is also regulated by adrenocorticotrophic hormone (ACTH) or not. ACTH (0.25 mg) was injected intravenously to 17 patients with primary hyperparathyroidism PHP, 7 patients with urolithiasis, 7 patients with malignant hypercalcemia, and 6 control subjects. Serum calcium was significantly increased in only PHP. The serum calcium increase rate showed a significant positive correlation with serum alkaline phosphatase, and a negative correlation with the preinjected serum calcium. PTH was slightly increased in all four groups. Serum cortisol and ACTH concentrations were not significantly different among the groups. PTH concentration in a culture medium of parathyroid tissues increased after ACTH addition. Serum calcium was significantly increased after ACTH injection in an adrenalectomized rat, and decreased in a parathyroidectomized rat. From our data and those of others, it appears that ACTH acts on the adrenal glands to decrease the serum calcium concentration, and might act directly on the parathyroid gland or bones to increase it.
PubMed ID: 3008538
Appears in Collections:Vol.31 No.12

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