複雑性尿路感染症に対するpiperacillinの臨床的検討

Abstract

1)複雑性尿路感染症74例にPIPC 4 g (2回分割点滴静注)の投与をおこなっところ著効9例, 有効34例, 無効31例であった.高齢者, 糖尿病合併例, 留置症例では有効率は有意に低値であった.手術により基礎疾患が排除され, 尿流障害は改善された.2)細菌学的効果では, 消失率は67.4%(分離菌95株中64株)であり, E. coli 91.6%, Proteus 75%, Klebsilla 53.8%, Pseudomonas 52.4%, Serratia 36.4%であった.また投薬後出現細菌は9種18株で, Serratiaが27.8%ともっとも多かった.3)自覚的副作用の発現率は2.5%.臨床検査値の変動はGOT 2.5%, GPT 1.7%, ALP 0.8%に上昇をみたが, ともに一過性で重篤なものではなかった

Clinical efficacy of piperacillin against 74 cases with complicated urinary tract infection was examined. Piperacillin was administered at the dose of 4 g (2 g twice daily) through intravenous drip infusion. The overall clinical value was rated in "excellent", in 9 cases, "moderate" in 34 cases and "poor" in 31 cases with a total efficacy of 58.1%. In the analysis of clinical values based on background, its efficacy was statistically significantly lower in the patients at a higher age, those with complication of diabetes mellitus, and those with indwelling catheter. In operated cases compared to non-operated cases, it was suggested to be more effective for improving the disturbances in urinary flow as a result of the removal of the underlying conditions by the operation. As to bacteriological efficacy, 64 out of 95 strains (67.4%) isolated were eradicated following its administration. Microbes which appeared after its dosing belonged to 9 classes of 18 strains, of which 5 strains (27.8%) of Serratia were identified. Side effects were 2.5% (3/119), no serious cases appeared. Changes in laboratory examination results were elevated GOT (2.5%), GPT (1.7%), and ALP (0.8%) values, all being transient hanges.