前立腺肥大症に対するアリルエストレノールの臨床経験

Abstract

本剤50 mg/日を26症例に投与し, 10週間以上投与し得た24例において, 1)自覚的排尿困難度は79.2%の例で改善をみた.2)尿流量測定では13例中6例に明らかに改善し, また, 経直腸的超音波断層法による前立腺重量計測では, 投与前後において有意差はみられないものの19例中10例に明らかな縮小がみられた.3)副作用としては, ポテンツ低下, めまいが各1例にみられたが軽度であった

Clinical effects of allylestrenol were studied on 26 patients with benign prostatic hypertrophy with urinary disturbances. Allylestrenol was administered at the dose of 50 mg/day given twice a day for more than 10 weeks. Evaluation of the drug efficacy was made based on urodynamic and ultrasonographic findings. One of the 26 cases dropped due to a side-effect (vertigo) and another due to defusal of treatment. The efficacy rate was 50%. Side-effects were observed in 2 cases (1 with decrease of potency and the other with vertigo) but were mild. It was concluded that allylestrenol is useful for treatment of urinary disturbances caused by prostatic hypertrophy.