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Title: 腎細胞癌の治療 第2報: ACNU&VBL併用療法
Other Titles: Chemotherapy of renal cell carcinoma. 2. Combined chemotherapy using ACNU and VBL
Authors: 小林, 幹男  KAKEN_name
今井, 強一  KAKEN_name
中井, 克幸  KAKEN_name
熊坂, 文成  KAKEN_name
鈴木, 孝憲  KAKEN_name
伊藤, 善一  KAKEN_name
山中, 英寿  KAKEN_name
杉原, 志朗  KAKEN_name
Author's alias: KOBAYASHI, Mikio
IMAI, Kyoichi
NAKAI, Katsuyuki
KUMASAKA, Fuminari
SUZUKI, Takanori
ITO, Yoshikazu
YAMANAKA, Hidetoshi
Keywords: Renal cell carcinoma
Combination of chemotherapy ACNU & vinblastine
Prophylactic treatment
Issue Date: Mar-1986
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 32
Issue: 3
Start page: 375
End page: 383
Abstract: 腎細胞癌の19例に根治的腎摘除術後,ACNU (nimustine hydrochloride) & VBL (vinblastine sulfate)療法を施行した.肺,胸膜への転移を有する進行癌の1例は効果判定にてNCであった.予防的投与群は18例で,うち再発は5例(平均観察期間22.3ヵ月)であった.本療法は副作用がかなり強く,投与量についてはよく検討すべきである
Nineteen patients with renal cell carcinoma who had undergone radical nephrectomy have been treated with a combination of chemotherapy and partly hormonal therapy using ACNU, vinblastine and chloromadinone acetate. The efficacy of the combination therapy in advanced renal cell carcinoma was studied and only one out of nineteen cases having lung and pleural metastasis shows no change lasting from one to eighteen months. The prophylactic efficacy was studied in eighteen patients with stage I to IVA renal cell carcinoma (contained one patient with stage IVA renal cell carcinoma who had undergone radical nephrectomy and coecum resection for coecum invasion). Tumor recurrence occurred in 5 cases, that is 5 cases within 1 year and 1 case within 2 years. The combination of chemotherapy using ACNU & vinblastine must be used carefully for severe side effects.
PubMed ID: 3460318
Appears in Collections:Vol.32 No.3

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