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Title: 蓚酸カルシウム結石患者における外来蓚酸負荷試験の検討
Other Titles: Oxalate loading test for outpatients with calcium oxalate stones
Authors: 加藤, 雅史  KAKEN_name
Author's alias: Kato, Masafumi
Keywords: Calcium oxalate stone
Oxalate loading test
Urinary oxalate
Hyperabsorption of oxalate
Issue Date: Mar-1986
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 32
Issue: 3
Start page: 351
End page: 360
Abstract: 成人男子蓚酸カルシウム結石患者50名(単発群25名,再発群25名)と健康成人対照群9名に対し,ホウレン草を用いた食事による蓚酸負荷試験を施行し,負荷前2時間および負荷後6時間の尿中蓚酸量,カルシウム量および尿量を測定し,蓚酸吸収能力からみた結石再発riskを検討した.1)負荷前2時間の平均尿中蓚酸排泄量および尿中カルシウム排泄量は,3群間に有意差を認めなかった.2)負荷後6時間の平均尿中蓚酸排泄量は単発群および再発群が対照群より有意に高値を示したが,尿中カルシウム排泄量では3群間に有意差を認めなかった.3)負荷前後での単位時間当りの蓚酸排泄量の増加率をみると,推計学的に対照群より再発群が有意に高値を示した.4)負荷後の尿中蓚酸排泄量とカルシウム排泄量の関係は,対照群および単発群と再発群を合わせた結石群において相関は認められなかった.5)負荷後尿中蓚酸排泄量が高値のものは結石再発riskが高いと思われた
A spinach loading experiment was performed on 9 normal subjects, 25 outpatients who were single calcium oxalate stone formers and 25 recurrent calcium oxalate stone formers. The experimental diet contained 445 mg of total oxalate, 163 mg of soluble oxalate and 115 mg of calcium. Urinary oxalate excretion was observed 2 hrs before and 6 hrs after the experimental diet was consumed. There was no significant difference in urinary oxalate excretion in preloading urine of normal subjects and stone formers. However, urinary oxalate excretion in postloading urine was significantly elevated in stone formers. This loading test is recommended as a simple and valuable screening method of hyperabsorption of oxalate on outpatients with calcium oxalate stones.
PubMed ID: 3728240
Appears in Collections:Vol.32 No.3

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