神経因性膀胱に対する塩酸オキシブチニンの臨床効果

Abstract

神経因性膀胱患者10症例に塩酸オキシブチニン1回2 mg 1日3回, 1日量6 mgを投与し, 臨床症状とともに下部尿路機能に及ぼす影響を膀胱内圧測定, 残尿量測定を施行して検討した.1)膀胱内圧測定では本剤投与により初発尿意量は約34%増加し有意差を認めたが, 最大膀胱容量, 最高内圧に関しては明確な変動は認められなかった.残尿量においても, 投与前後における変動は認められなかった.2)自覚症状に対しては頻尿, 尿失禁, 尿意切迫感に対して満足すべき有効率を示した.総合効果においては, 有効以上の有効率で50.0%を得た.3)副作用は10例中4例に認められ, 口渇3例, 下痢1例であった.いずれも一過性, 軽度なもので重篤な副作用は認められなかった

Clinical effects of oxybutynin hydrochloride on lower urinary tract function at a dosage of 2 mg given orally three times daily (6 mg/day), were studied on 10 patients with neurogenic bladder by cystometry and measurement of residual urine. There was a significant increase, of about 34% in FDV, but no significant changes in MBV, or maximum voiding pressure of residual urine after administration. Urinary frequency, incontinence and urgency in subjective symptoms were decreased in patients given this drug. The effective rate (excellent and good) was 50% in global evaluation. Side effects were observed in 4 out of 10 patients; 3 had dry mouth and 1 had diarrhea. There were no serious side effects. These findings suggested that oxybutynin hydrochloride may be a useful drug for neurogenic bladder.