前立腺癌剖検例の病理学的検討

Abstract

前立腺癌剖検例27例について, 生検・剖検時のgradeの変化, 原発巣・転移巣間のgradeの相違について検討した.1)遠隔転移を認めたものは25例(92.6%)であり, 転移部位はリンパ節が最も多く25例全例に認め, 次いで骨, 肺の順に多かった.2)生検, 剖検時にgradeの変化が認められたものは4例(14.8%)であり, 剖検時原発巣と転移巣のgradeの相違が見られたものは3例(11.1%)であった.3)生検, 剖検時にgradeの変化を認めた群と剖検時の原発巣・転移巣間でgradeの相違を認めた群は以下のような共通の傾向を示した.いずれもgrade不変化群とgradeの相違を認めない群に比し, i)高齢である, ii)生存期間が長い, iii)より低分化に変化しているものが多い, iv)治療法の種類や量には関係なく, 何らかの治療法に反応している

In 27 cases of prostatic cancer, the histopathologic prostatic picture at the time of autopsy was compared with that in biopsy and that of metastatic lesions at autopsy. A change in the grade between in biopsy and in autopsy was confirmed in 4 cases (14.8%). A change in the grade between the prostate and metastatic lesion at the time of autopsy was confirmed in 3 cases (11.1%). The cases that had a change in the grade, had a common tendency: being older, having a longer clinical course than the no grade-change group, changing to a higher grade.