A comparison between effects of pyruvate and herb medicines in preventing experimental oxalate urolithiasis in rats

Abstract

実験的蓚酸カルシウム結石食(グリコール酸食)をウイスター系ラットに投与すると4週後には尿路結石の高度の沈着をみる.結石形成抑制作用を比較する目的で, ピルビン酸ナトリウムと漢方製剤である猪苓湯と裏白樫をそれぞれこの結石形成食に添加した.結石形成食群では高度の尿路結石症を認めたのに対し, ピルビン酸塩群では結石形成は認めなかった.猪苓湯群及び裏白樫群でも結石形成抑制を認めた.尿中蓚酸の排泄はすべての群で高かったが, ピルビン酸群とグリコール酸群では著明であり, 4週に近づくに従い低下し, その減少傾向は漢方群では著しかった.ピルビン酸群のみに尿中クエン酸排泄の増加が見られた.猪苓湯群ではグリコール酸群に比し, 尿量と尿中マグネシウム及びカルシウムの排泄が多い傾向を示した.以上より, ピルビン酸塩の強い結石形成抑制作用と比較すると, 漢方製剤は5%ピルビン酸塩添加の抑制作用には及ばなかった.漢方群では3週以後尿中蓚酸排泄減少し, 更に猪苓湯群では尿量と尿中マグネシウムの排泄増加傾向なども認めた

Sodium pyruvate, choreito (a herbal preparation), and urajirogashi (a herb) were added to a calcium-oxalate lithogenic diet (a glycolic-acid diet) to determine their effects in preventing lithogenicity. Male Wistar-strain rats which had been fed the glycolic-acid diet developed marked urinary calculi within 4 weeks. Rats in the groups fed a pyruvate diet had, however, almost no stones in the urinary system. The choreito and urajirogashi were slightly less effective than the pyruvate. Urinary oxalate excretion was high in all the groups during the experiment, especially in the pyruvate and the glycolic-acid groups, but, it was relatively lowered in the herb groups, especially towards the end of the experiment (p less than 0.05). Urinary citrate excretion was high in the pyruvate group, but it was significantly low in the other groups. In the choreito group, remarkable increases in urinary volume and magnesium excretion were observed; however, they were statistically non-significant and urinary calcium excretion was higher than in the glycolic-acid group during the experiment. Therefore, it can be concluded that choreito and urajirogashi may have some beneficial effect though any such effect is inferior to that of pyruvate, in preventing calculi formation, partly by decreasing the urinary oxalate excretion; increased urine volume and magnesium excretion may also have some other, additional effects in the choreito group.