尿路上皮腫瘍患者および健康人におけるN-acetyltransferase phenotypeについての検討

Abstract

尿路上皮腫瘍患者及び健康人において, SMZを用いるWeber and Brennerの方法に準じてN-acetyltransferase phenotypeを検討した.1) Slow acetylator phenotypeの頻度は, 全体では144例中16例であり, 各群別にみると正常対照群25例中1例, 検診群57例中10例, 自然発生尿路上皮腫瘍患者群42例中3例および職業性尿路上皮腫瘍患者群20例中2例であった.2) Slow typeの頻度は, 腫瘍患者群の方が正常対照群より高い傾向を示したが有意差はなかった

Several arylamines can act as human urothelial carcinogen and N-acetyltransferase, human liver enzyme, might play a role in the detoxication of these carcinogenic substances. N-acetyltransferase phenotype in man is genetically regulated and divided into the rapid type and the slow type. The N-acetyltransferase phenotype was determined to investigate the susceptibility for bladder cancer in the slow acetylator phenotype using the method reported by Weber and Brenner. The frequency of the slow acetylators was 16 of the 144 subjects (11.1%); 1 of the 25 controls (4.0%), 10 of the 57 chemical workers (17.5%), 3 of the 42 spontaneous urothelial cancer patients (7.1%) and 2 of the 20 occupational urothelial cancer patients (10.0%). These results showed no significant association between the slow acetylator phenotype and the urothelial cancer. These results seemed to be caused by the low ratio of the slow acetylator in Japanese people.