Comparative study of the effects of pyruvate and CG-120 in preventing experimental oxalate urolithiasis in rats

Abstract

実験的蓚酸カルシウム結石食(3%グリコール酸食)をウイスター系ラットに投与すると4週後には尿路結石の形成を見る.本実験食にクエン酸塩製剤であるCG-120とピルビン酸ナトリウムを添加したところ, 後者では結石形成はほとんどなく, CG-120群でも結石形成を抑制した.この両添加群において, 尿中クエン酸排泄の著しい増加を見た.各群間の尿中蓚酸の排泄の差は明らかでなかった.4週後の腎組織への蓚酸カルシウムの沈着はピルビン酸群ではほとんど認められず, CG-120群では軽度認められた

Male Wistar-strain rats which had been fed a calcium-oxalate lithogenic diet (a glycolate diet) developed urinary calculi in 4 weeks. Sodium pyruvate or CG-120 (a mixture of citrate salts) had been added to this diet to determine its effect in preventing lithogenicity. Rats in the group fed a pyruvate diet had, however, almost no stones in the urinary system. Rats in the CG-120 group showed results somewhat similar to those in the pyruvate group. Increased urinary citrate excretion was observed in both groups and could be implicated as the main inhibitory factor in stone formation. Therefore, it can be concluded that CG-120 exerts a beneficial effect close to that of pyruvate in preventing calculi formation and that both substances cause a high citrate excretion in urine.