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タイトル: | 尿中NAGおよびγ-GTP活性からみたCDDP腎障害 : Fosfomycin併用投与の効果について |
その他のタイトル: | Urinary NAG and gamma-GTP activities as indicators of CDDP renal toxicity: effect of fosfomycin on CDDP renal toxicity |
著者: | 吉田, 謙一郎 高橋, 卓 中目, 康彦 斉藤, 博 堀内, 晋 金親, 史尚 根岸, 壮治 |
著者名の別形: | YOSHIDA, Ken-Ichiro TAKAHASHI, Taku NAKAME, Yasuhiko SAITOH, Hiroshi HORIUCHI, Susumu KANEOYA, Fumihisa NEGISHI, Takeharu |
キーワード: | CDDP renal toxicity Urinary NAG and γ-GTP activities FOM |
発行日: | Sep-1986 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 32 |
号: | 9 |
開始ページ: | 1237 |
終了ページ: | 1245 |
抄録: | 10症例の泌尿器科領域の悪性腫瘍患者において, Cisplatin (CDDP)投与前の尿中NAG及びγ-GTPが正常範囲内にある場合, Fosfomycinの併用はCDDP投与後のこれらの増加を抑制した Using urinary N-acetyl-beta-D-glucosaminidase (NAG) and gamma-glutamyl transpeptidase (gamma-GTP) activities as the indicator of renal toxicity, the effect of fosfomycin (FOM) on cisdichlorodiamineplatinum (CDDP) renal toxicity was studied in 10 patients with urological malignant tumors. Regimen of chemotherapy was daily 20 mg of CDDP and 800 mg of administered by drip infusion for 5 days and 40 mg of adriamycin injected in one-push on day 1. FOM was not used at 1st cure. At 2nd cure, daily 2 g X 2 of FOM was administered for eleven days from the day before CDDP administration. Urinary NAG and gamma-GTP were measured for eleven days continuously in both 1st and 2nd cure. Effect of FOM on CDDP renal toxicity was discussed by comparison of the urinary NAG and gamma-GTP activities between 1st and 2nd cure. The results showed that urinary NAG and gamma-GTP activities following CDDP administration were deeply influenced by these activities before CDDP administration and the combined therapy of FOM had tendency to reduce CDDP renal toxicity when urinary NAG and gamma-GTP activities before CDDP administration were in the normal range. |
URI: | http://hdl.handle.net/2433/118919 |
PubMed ID: | 2880486 |
出現コレクション: | Vol.32 No.9 |
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