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Title: 進行性膀胱癌の多剤併用化学療法
Other Titles: Combination chemotherapy of advanced bladder cancer
Authors: 清原, 久和  KAKEN_name
Author's alias: KIYOHARA, Hisakazu
Keywords: Combination chemotherapy
Bladder cancer
Cis-platinum
Adriamycin
Issue Date: Dec-1986
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 32
Issue: 12
Start page: 1925
End page: 1930
Abstract: Patients with carcinoma of the urinary bladder have a poor prognosis. When distant metastasis develops, such patients seldom survive for more than several months. For them, surgery and/or radiotherapy are of little value, and systemic chemotherapy has been thought to be the most useful treatment. Forty-six patients with advanced transitional cell carcinoma, including bladder cancer, (33 bladder, 9 ureter, 4 renal pelvis cases) were treated by a three drug combination chemotherapy, using two protocols (protocol I: adriamycin + cyclophosphamide + 5-fluorouracil, protocol II: adriamycin + cyclophosphamide + cis-platinum). Protocol I induced responses in 5 of the 24 patients (21%, 1 complete response, 4 partial responses), and protocol II in 7 of the 22 patients (32%, 1 complete response, 6 partial responses). The overall response rate was 26%. The durations of response (median duration 5.1 months) and of survival (median duration 11.3 months) in all responders were relatively short. The three-combination chemotherapy, especially protocol II, was effective against transitional cell carcinoma of the urinary tract, but the results were not satisfactory.
URI: http://hdl.handle.net/2433/118981
PubMed ID: 3825829
Appears in Collections:Vol.32 No.12

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