陰茎癌におけるSCC抗原の臨床的検討

Abstract

扁平上皮癌に特異的であるとされるSCC抗原を用い, 陰茎癌における腫瘍マーカーとしての有用性について検討した.1)陰茎腫瘍という前提で, 1.0 ng/mlを正常上限とすると, 陽性率71.4%, 偽陽性率0%となり, 診断に有用であると考えられた.2)血清SCC抗原の経時的推移は, 臨床経過とよく合致し, 治療効果判定, 病勢のmonitaringに有用である

A squamous cell carcinoma-related antigen (SCC-Ag), which has been recognized as a tumor marker of cervical cancer of the uterine, was detected in the serum with a radioimmunoassay and its clinical usefulness in penile cancer was evaluated. Seven serum samples of penile cancer, one of Paget's disease and two of condyloma acuminatum were analyzed for the SCC-Ag level. The mean +/- standard deviation of serum SCC-Ag level and positive rate (greater than 2.0 ng/ml) were 1.6 +/- 1.75 ng/ml and 14%. Neither pathological staging nor cell grading of penile cancer showed any relation to the serum SCC-Ag level. When the tumor of the penis has been recognized and a cut-off value of 1.0 ng/ml used, the positive rate of penile cancer was 71.4% and false positive rate of other benign penile tumors was 0%. Serum SCC-Ag values were changed parallel in to the clinical course in three patients. These results suggest that the detection of the serum SCC-Ag value may be of use for detection of penile cancer and monitoring of these patients.