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タイトル: 膀胱腫瘍における膜抗原の検討 - ABH isoantigenとThomsen-Friedenreich antigenについて -
その他のタイトル: The study of cell surface antigens in bladder tumors: ABH-isoantigen and Thomsen-Friedenreich antigen
著者: 小林, 弘明  KAKEN_name
著者名の別形: KOBAYASHI, Hiroaki
キーワード: Bladder tumor
ABH isoantigen
T antigen
Mapping
発行日: Apr-1987
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 33
号: 4
開始ページ: 535
終了ページ: 544
抄録: 膀胱腫瘍85例及び34例のmapping標本におけるABH-isoantigen (ABH-ag)とThomsen-Friedenreich antigen (T-ag)の有無を, Avidin-Biotinperoxidase Complex (ABC)法を用いて調べ, 腫瘍マーカーとしての有用性を検討した.1) ABH-ag及びT-agの抗原性の消失率は, 異型度, 進達度がすすむほど有意に高くなった.2)どちらか一方の抗原性が消失していた症例中両方とも抗原性が消失している場合は, 65%であった.3) 56例
ABH isoantigen (ABH-ag) and Thomsen-Friedenreich antigen (T-ag) was investigated by the Avidin-Biotin peroxidase Complex (ABC) method in 85 bladder tumors. Furthermore mapping of epitheliums and related expression of ABH-ag and T-ag was studied in 34 bladders surgically removed for cancer. There was a correlation between histological grade, stage and deletion of the antigenicity (ABH-ag and T-ag). The recurrence rate after surgery of the cases with the normal antigenicity (ABH-ag and T-ag) was significantly lower than that of the cases with the abnormal antigenicity. The 5-year survival rates of the cases with the normal antigenicity (ABH-ag and T-ag) was relatively higher than that of the cases with the abnormal antigenicity. Combination of two markers (ABH-ag and T-ag) was significantly more effective than the single marker. The deletion of the antigenicity (ABH-ag and T-ag) was related to the intramural lym hatic invasion, the intramural venous invasion and the intramural histological mode of spread in mapping of 34 bladder tumors. Fourteen cases of 34 mapped bladders had the abnormal ABH-antigenicities in the bladder tumors and the normal ABH-antigenicities in the other epitheliums. Eleven cases of 34 mapped bladders had the abnormal T-antigenicities in the bladder tumors and the normal T-antigenicities in the other epitheliums. The cases that expressed the abnormal antigenicities of the tumors with the normal antigenicities of the other epitheliums had good clinical course after operation. There was no relation between the abnormal epitheliums (dysplasia, hyperplasia and Brunn's nest) and the antigenicity. Therefore the study of expression of ABH-ag and T-ag in bladder epitheliums may be valuable for predicting the malignant potential in bladder tumors.
URI: http://hdl.handle.net/2433/119105
PubMed ID: 3618425
出現コレクション:Vol.33 No.4

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