担癌生体のリンパ節の臨床病理学的検討 - とくにSinus reactionについて -

Abstract

尿路悪性腫瘍16例について検討した.low stageの場合は正常像やsinus histiocytosisを示す場合が多く, high stageでしかもリンパ節転移が見られるにつれて, mixed sinus reactionやsinus catarrhの像がみられる傾向を認めた.このことは一般に細胞性免疫として考えられている生体の"defense mechanism"というよりは腫瘍よりの何らかの物質に対する"immunity response"の像と考えるべきであると思われる

The sinus reaction of lymph nodes from tumor-bearing patients was classified into 5 categories, normal (N), sinus histiocytosis (SH), mixed sinus reaction (M), sinus catarrh (SC) and not classified (NC), according to the definition of Thoresen (1982). As a result, at the low stage, 93.8% were N and SH, while at the high stage, 97.0% were M, SC and NC. The same results were also obtained, when the transfer of the lymph nodes was taken into consideration. On the other hand, when the lymph nodes were studied from the distant lymph nodes area (DLA) and regional lymph node area (RLA) according to the position of the pathogen, SC was the most with DLA, since all cases were at the high stage. With RLA, SH was the most at 47.6% at the low stage, while at the high stage. SC and NC indicated 66.0%. Therefore, the sinus reaction can be used to estimate the degree of the response to the cancer and the diagnosis of tumor-bearing patients.