尿中逸脱酵素,蛋白に関する研究 第1報: 泌尿器科疾患でのN-Acetyl-β-Glucosaminidase

Abstract

腎・尿路疾患79例, 精路疾患60例についての検討で, 尿中NAG活性は, 腎炎, 糖尿病性腎症, 水腎症などの腎尿路疾患や留置カテーテルのある前立腺肥大症や前立腺炎症例では健常者に比べ有意に高値を示した.NAG isoenzymeは尿ではA/B=78.0/21.9であるのに対し精漿ではA/B=24.9/71.0と明らかに異なっていたが, それだけでは両者を鑑別することは難しかった.しかし, 尿中NAG活性値が高くてしかも尿中NAG-isoenzymeのA/B比が精漿での-24.9/75.0-の割合に近い場合, 精路疾患特に前立腺疾患の有無について考慮する必要がある

N-Acetyl-beta-glucosaminidase (NAG) exists in renal tubules and seminal tract. We measured the NAG level in patients with urinary tract and seminal tract diseases and evaluated its clinical significance. The urinary NAG level was high in renal tubular function disorders such as glomerulonephritis, diabetic nephropathy and hydronephrosis. In these patients, NAG-isoenzyme studies indicated that the A-type isoenzyme decreased while the B-type isoenzyme increased. On the other hand, in the seminal tract disease patients, the urinary NAG level was high in benign prostatic hypertrophy with a catheter indwelling and in prostatitis. Urinary and seminal NAG-isoenzymes were measured in normal subjects. The isoenzyme patterns for urinary NAG and seminal NAG differed. The urinary NAG isoenzymes were measured in acute prostatitis patients, we found that the A-type isoenzyme decreased and the B type increased. In conclusion, when the A/B ratio of the NAG-isoenzyme is close to 24.9/75.0 in the urine, the presence of urological diseases in which seminal plasma could be mixed in, especially prostatic diseases, should be suspected.