ヒト精液中のNAG活性についての研究 : 精漿中ならびに精路組織におけるγ-GTP活性との関係および精漿中ムコ蛋白濃度との関係について

Abstract

1)無精子症を除く男子不妊症66例について, 精漿中のNAG, γ-GTP活性, およびムコ蛋白濃度について測定した.NAG活性は2, 092±794 mU/ml, γ-GTP活性は10, 941±4, 179 mIU/ml, ムコ蛋白濃度は28.0±5.7 mg/mlであった.2)精漿中のNAG活性とγ-GTP活性はきわめて高い相関を示したか, ムコ蛋白濃度とγ-GTP活性とは低い相関を示し, ムコ蛋白濃度とNAG活性とは, 良い相関を示さなかった.3)精路組織についてみるとγ-GTP活性はその精細管がSertoli細胞のみを示した睾丸組織できわめて高く, また前立腺外腺組織でも高い値を示した.副睾丸においては尾部において高い値を示したが, 頭部ではやや低値であった.NAG活性についてみると副睾丸頭部, 前立腺内腺で高い値を示したが, γ-GTP活性と異なり睾丸組織では低値であった.精嚢腺や精管においては両酵素活性とも低値であった

N-Acetyl-beta-D-glucosaminidase (NAG) and gamma-glutamyl transpeptidase (gamma-GTP) activities in seminal plasma obtained from male infertile patients and these activities in reproductive tissues obtained from cryptorchids and patients with bladder tumors were studied. Seminal mucoprotein concentration was also measured. The mean NAG and gamma-GTP activity in seminal plasma was 2, 092 +/- 794 mU/ml and 10, 942 +/- 4, 179 mIU/ml, respectively. The mean seminal mucoprotein concentration was 28.0 +/- 5.7 mg/ml. In seminal plasma, a significant correlation was obtained between NAG and gamma-GTP (p less than 0.001). and between gamma-GTP and mucoprotein concentration (p less than 0.05). However, there was no correlation between NAG and mucoprotein concentration. In the reproductive tissue high gamma-GTP activity was observed in the testicular tissue and in the external gland of the prostate. The activity in the epididymis was higher in the tail than in the head. High NAG activity was observed in the epididymal head and in the internal gland of the prostate. In the testicular tissue, NAG activity was low. These findings showed that in the seminal plasma NAG and gamma-GTP activities were closely related but in the reproductive tissue, these activities located in different areas.