男子非淋菌性尿道炎の実態とMinocyclineによる治療効果 クラミジアまたはウレアプラズマ感染症について

Abstract

1) STDと考えられる男子尿道炎患者48例について調査した結果, 淋菌性2例で原因菌不明は23例であった.クラミジア陽性例は9例(19%), ウレアプラズマ陽性例は6例(12%)であった.2)クラミジア陽性例でウレアプラズマが同時に分離された尿道炎は1例もなかった.3)クラミジアまたはウレアプラズマ陽性NGUで尿道分泌物は漿液性のものが多く, 膿尿などは軽度であった.4)クラミジアまたはウレアプラズマ陽性のNGUに対してMINOを投与した結果, クラミジア性NGUで78%, ウレアプラズマ性NGUで67%の総合臨床効果を得た

Thirty-nine male patients with urethritis were studied for gonorrhoea or non-gonorrhoea infections. Only 2 patients were infected with N. gonorrhoeae, the other 37 patients were non-gonorrhoea urethritis (NGU). In 9 of these patients, C. trachomatis was identified and in 6 patients, U. urealyticum was isolated. No chlamydial urethritis was combined with ureaplasma. There was no clinical difference between chlamydia and ureaplasma infection, such as serous urethral discharge or mild pyuria. Minocycline was given orally at the dose of 200 mg daily for 7 to 42 days to these patients. Seven of the 9 patients (78%) with C. trachomatis and 7 of the 6 patients (67%) with U. urealyticum infection showed improvement of subjective and objective symptoms after minocycline. In no case, was an adverse reaction noted. Minocycline was effective in the treatment of both C. trachomatis and U. urealyticum urethral infection.