Effect of combined therapy in patients with urolithiasis of lower urinary pH

Abstract

酸性尿を示す尿路結石患者を対象として, アロプリノール, サイアザイド, 全身アルカリ化による多剤併用療法の効果について検討した.対象症例は90例, 経過観察期間は1年から3年, 平均18ヵ月であった.結石消失率は腎結石, 尿管結石, 膀胱結石でそれぞれ60%, 74%, 20%であった.全身アルカリ化と点滴静注よる大量のサイアザイド利尿剤, カリウム, マグネシウム投与による重篤な副作用や合併症は認められなかった

The effect of combining therapy with hydrochlorothiazide, allopurinol and systemic alkalization for urolithiasis with lower urinary pH was examined. A total of 90 patients were followed up for 1 to 3 years, the average follow up period being 18 months. The total stone disappearance rate was 60% (kidney stone), 74% (ureter stone) and 20% (bladder stone). Large amounts of thiazide diuretics, potassium and magnesium were intravenously administered to a patient with systemic alkalization at slow infusion speed, neither serious side effects nor complication occurred. This method is simple and an effective remedy. It is also very practical in the developing countries of the third world.