Single photon emission computed tomography(SPECT)を利用した各種腎疾患の99mTc-DMSA腎摂取率測定

Abstract

1) 73症例の各種腎疾患例を対象に, SPECTによる99mTc-DMSA腎横断々層イメージより腎摂取率を求める腎機能検査法を77回行った.2) 73例に77回検査を行なった総腎容積と総腎摂取率, 143腎の腎容積と腎摂取率の相関計数はr=0.3509, r=0.5433であった.3) 73例中Ccr値を測定し得た62例のCcr値と総腎容積および総腎摂取率との相関係数はr=0.2352, r=0.8854で総腎摂取率とよく相関した.4) 99mTc-DMSA腎摂取率は腎容積と比較し, より正確な腎機能を表すものと推察できる.5)成人正常男女それぞれ10例40腎の腎容積と腎摂取率は, それぞれ男子では右腎220 ml, 26.8%, 左腎239 ml, 27.6%, 女子ではそれぞれ206 ml, 26.4% 237 ml, 27.9%であった

To determine renal function, 99mTc-DMSA renal uptake was measured from renal tomographic images obtained by single photon emission computed tomography (SPECT). A total of 77 tests was conducted on 73 patients with various diseases in the kidneys and urinary tract to determine renal uptake. The correlation coefficient(r) between total renal volume and total renal uptake was 0.3509 and that between renal volume and uptake of 143 kidneys was 0.5433. In 62 patients whose creatinine clearance could be measured, the correlation coefficient between creatinine clearance and total renal volume was 0.2352, and that between creatinine clearance and total renal uptake was 0.8854, that is, creatinine clearance correlated well with renal uptake. Renal volume and uptake determined in 10 normal male and 10 normal female adults were 220 ml and 26.8% for the right kidney and 239 ml and 27.6% for the left kidney for the males and 206 ml and 26.4% (right) and 237 ml and 27.9% (left) for the females. This method, which requires no blood or urine collection, is very useful as an individual kidney function test to evaluate individual kidney function and to understand kidney function before and after operation in patients with renal and urinary diseases.