腎機能と微量元素に関する臨床的研究

Abstract

1)血清Al値は腎機能障害が高度になるほど高値を示し, 慢性腎不全患者では異常高値を示した.2)血清Cu値は正常者, 腎機能障害者, 透析患者とも, ほぼ同程度の値を示し, 有意差はなかった.3)血清Zn値は正常者に比べ腎機能障害の程度が高くなるほど低値を示した.4)血清Ni値は正常者に比べて腎機能が低下するにつれて次第に低値を示した.5)血清Mn値は正常者に比べ腎機能障害が高くなるほど, 低値を示した.6)血清Al値, 血清Zn値, 血清Ni値, 血清Mn値を測定することは, 臨床的に腎機能の状態を知るうえで有用であると考えた

The serum trace elements aluminum (Al), zinc (Zn), nickel (Ni), and manganese (Mn), and creatinine clearance (Ccr) were measured in twenty normal volunteers and 40 patients; 5 patients had mild renal dysfunction, 10 patients had chronic renal failure 5 patients had uremia and 20 patients had been undergoing chronic hemodialysis. Serum Al, Cu, Zn, Ni and Mn were measured with a flameless atomic absorption spectrophotometer. Serum Al levels increased with decrement of the Ccr value. The serum Al level was abnormally high in chronic hemodialysis patients. The serum Cu level in the patients was similar to that in the healthy subjects. Serum Zn, Ni and Mn levels decreased with the decrement of the creatinine clearance level. These results suggest that measurement of serum Al, Zn, Ni and Mn levels can be used as an indication of renal function clinically. In conclusion, serum Al, Zn, Ni and Mn levels are clinical indicators of renal function.