睾丸腫瘍の患者対照研究

Abstract

睾丸腫瘍の発生における母親の要因を明らかにするために, 37人の睾丸腫瘍患者に対してmatched pair方式の患者対照研究を行った.単変量解析の結果, 統計学的には有意ではなかったが睾丸腫瘍患者群は対照群に比べて以下の特徴がみられた.本人を妊娠する前の母親の肥満度が低かった.本人を出産した時の母親の年齢が高かった.本人に対する母親授乳期間が長かった.本人の出生順位が下位であった.母親の出産回数が少なかった.そして, 以上の6つの要因をすべて含めた多変量解析を行ったところ, 睾丸腫瘍患者の母親は対照群の母親に比べて出産回数が有意に少ないという結果を得た(p=0.02).その他の5つの要因には有意差がみられなかった.母親の内因性ホルモン環境が睾丸腫瘍の発生に関与してい可能性が示唆される

A study on the possible association of maternal factors with testicular cancer was undertaken. Information was obtained from the mothers of testicular cancer cases (N = 37) and the mothers of men without the disease (N = 37). Comparisons were made between the two groups. The cases were collected from the records of nine hospitals, and the controls were selected from five Public Health Centers by individually matching the sex and the year of birth with the testicular cancer cases. The mothers of the cases had significantly fewer live births than the mothers of the controls (the adjusted odds ratio per live birth = 0.4, p = 0.02), when the five following variables had been simultaneously adjusted by the logistic regression analysis. Those five variables included the Quetelet's Index of mothers before pregnancy, the age at an index birth, the duration of breastfeeding for an index child, the birth order of an index child, and the number of induced abortions. The endogenous hormonal milieu of a mother may be associated with the occurrence of testicular cancer in her child.; PIP: A study on the possible association of maternal factors with testicular cancer was undertaken. Comparisons were made among 2 group of women: those mothers of testicular cancer cases (n=37) and those mothers of men without the disease (n=37). Cases were collected from the records of 9 hospitals, and controls were selected from 5 public health centers by individually matching the sex and year of birth with the testicular cancer cases. Mothers of the cases had significantly fewer livebirths than those mothers of the control group (the adjusted odds ratio per livebirths=0.4, p=0.02) when the 5 following variables were simultaneously adjusted by the logistic regression analysis: Quetelet's Index of mothers before pregnancy, age at index birth, duration of breastfeeding for an index child, birth order of an index child, and number of induced abortions. The endogenous hormonal milieu of a mother may also be associated with the occurrence of testicular cancer in her child. (author's modified)