前立腺炎症例におけるエノキサシンの精液内濃度について

Abstract

Ten patients with prostatitis were administered with Enoxacin (ENX), and the changes in its concentration in the seminal fluid were studied. For acute prostatitis patients, 600 mg/day of ENX was administered for 5 to 7 days, and for chronic prostatitis patients, 400 to 600 mg/day was administered for 7 to 17 days. Seminal fluid was obtained in the morning of examination and frozen until measurement. ENX was measured by the agar well method using E. coli. The concentration of ENX was 2.69 +/- 0.85 micrograms/ml and 3.98 +/- 2.49 micrograms/ml in acute and chronic prostatitis patients, respectively, and there was no significant difference between the two groups. When the dose and method of administration were compared, the mean ENX concentration was 3.65 micrograms/ml in the group administered 600 mg of ENX, while it was 2.60 micrograms/ml in the group administered 400 mg of ENX and not significantly different. When ENX was administered for 7 days, the mean ENX concentration was 3.13 micrograms/ml, but when it was administered for 14 days, it was 3.46 micrograms/ml slightly higher. These results indicate that since the concentration of ENX in the seminal fluid was higher than the minimum inhibitory concentration for the pathogens of prostatitis, ENX may be a clinically effective drug.