Ofloxacin concentration in human benign prostatic tissue after oral administration

Abstract

オフロキサシンを術前日600 mg, 手術日当日400 mgを経口投与した後の前立腺組織への移行について検討した.前立腺組織内濃度は平均5.51±1.79μg/g (range 3.62-9.70)で, 同時に採血した血清濃度との比率(前立腺/血清比)は1.06±0.31(range 0.55-1.54)であった.オフロキサシンは前立腺組織に良く移行し, 前立腺炎の起炎菌の最小発育阻止濃度に比べ高い値を示した

The penetration of ofloxacin (OFLX) into prostatic tissue was examined on 11 patients with benign prostatic hypertrophy. OFLX was administered orally in a dose of 200 mg, three times one day before and twice on the day of operation. The blood sample was taken 30 minutes before operation and prostatic tissue specimens were collected during operation. The mean concentration of OFLX in prostatic tissue was 5.51 +/- 1.79 micrograms/g (mean +/- SD) and 5.36 +/- 1.28 micrograms/ml in serum. The mean ratio of these concentrations was 1.06 +/- 0.31 (range 0.55-1.54). These findings indicate that OFLX will be valuable against bacterial prostatitis.