特発性男子不妊症に対するhMG-hCG 療法の有効性と精巣FSHレセプターの相関について

Abstract

48例の特発性男性不妊症患者の生検精巣組織のFSHレセプターを測定し, hMG-hCG療法の治療成績との相関を検討した.1) High affinity FSHレセプターを認めた34症例では約2/3の症例にhMG-hCG療法が有効であったがhigh affinity FSHレセプターを有しない14症例では1例以外無効であった.2) High affinity FSHレセプターを有する症例の中, 組織学的な造精障害が高度な症例では中等度ないし軽度の症例よりhMG-hCG療法の有効性が低かった.またこれらの症例では血清FSHレベルはhMG-hCG療法の有効性と相関しなかった

To investigate the relationship between testicular follicle stimulating hormone (FSH) receptors and the effectiveness of human menopausal gonadotropin (hMG-hCG) treatment in idiopathic male infertility, 48 infertile men were examined. Most of the 14 patients without detectable testicular high affinity FSH receptors did not show any increase in sperm count after the hMG-hCG treatment, whereas 23 of the 34 patients with FSH receptors responded to the treatment. In patients with FSH receptors, patients with a middle or high Johnsen's score count responded more than those with a low score count did. From the above results, it seems that both the presence or absence of testicular FSH receptors and the histological appearance of spermatogenesis predict responsiveness to hMG-hCG treatment in infertile men.