特発性男子不妊症における精巣FSHレセプターについて

Abstract

37例の特発性男性不妊症患者の生検精巣組織中のFSHレセプターを測定し, Johnsen's score countで示す組織学的な精細管の障害度との相関を検討した.1)精細管障害の軽度High score count群では全例にhigh affinity bindingを有するFSHレセプターを認めたが, 中等度の精細管障害のMiddle score count群の3分の1の症例, 高度障害のLow score count群の半数例ではFSHレセプターはhigh affinity binding siteを有さず, Bmax値の比較でも精細管障害の高度なほど, Bmax値は有意に低値を示した.2)以上より, 精巣FSHレセプターの異常は男子不妊症の一因を成していると考えられた

To ascertain whether abnormalities in testicular binding of follicle-stimulating hormone (FSH) are related with spermatogenic impairment found in idiopathic male infertility, we measured FSH receptors in testicular tissues obtained by biopsy from 48 infertile men. The 48 infertile men were divided into 3 groups by histological grading using Johnsen's score count, and testicular FSH receptors among these groups were compared. Although 9 of the 18 infertile men with low Johnsen's score count and 5 of the 15 men with middle score count had no obvious FSH binding sites with high affinity, all 15 men with a high score count had high affinity FSH binding sites. In connection with high affinity binding sites for FSH, maximum binding number (Bmax) decreased significantly with the degree of spermatogenic impairment, but the association constant (Ka) was similar among the 3 groups. The present findings demonstrate that the decrease in testicular high affinity binding sites for FSH is related with the degree of spermatogenic impairment found in idiopathic male infertility.