Can an intracavernous papaverine injection be used to diagnose arteriogenic impotence?

Abstract

インポテンスを訴える93例に塩酸パパベリンの陰茎海綿体内投与による勃起状態を観察(パパベリンテスト)し, 夜間陰茎勃起現象の記録, 性的視聴覚刺激による勃起の記録, penile-brachial index, 海綿体灌流による人工勃起の効果と比較検討した.パパベリンテストの効果は海綿体灌流による勃起発現流量および勃起維持流量と強い相関を示したが, penile-brachial indexとはまったく相関を示さなかった.したがって, パパベリンテスト陽性は流出路の閉鎖不全である静脈性インポテンスを否定し, 陰性は静脈性インポテンスを強く疑わせるが, パパベリンテストの結果から動脈性インポテンスを診断することはできないと考えられた

We injected papaverine into the corpus cavernosum of 93 patients with impotence, and compared the results with findings from nocturnal penile tumescence monitoring, psychogenic erection monitoring after sexual stimulation, penile-brachial indexes, and dynamic cavernosography. There was a significant correlation between the findings from papaverine injection and dynamic cavernosography, but there was no correlation between the papaverine findings and other tests including the penile-brachial index. We conclude that we can disregard the possibility of venous abnormality in those who respond to papaverine injection, but we cannot disregard the possibility of arteriogenic abnormality. We proved that papaverine injection cannot diagnose arteriogenic abnormality.