複雑性尿路感染症患者における血中Candida抗体の測定意義

Abstract

尿路感染症28例, 対照群11例について尿中Candidaの検出と血中Candida抗体の関連性および宿主免疫能との関係について検討した.1)尿中Candida陽性群のCandida抗体は明らかに上昇していたが, 71歳以上の高齢者では低値を示す症例があった.2)尿中Candida陽性群のHA titerとOKT-3, 4およびOKT-4/8比との間には正の相関があり, OKT-8との間に負の相関があった.3)治療前・後のHA titerの観察にて治療効果を知る可能性が示唆された

The serum candida antibody (HA titer) was measured by means of indirect hemagglutination test in 28 patients with complicated urinary tract infections (UTI) and 11 control subjects. The peripheral lymphocytes subsets (OKT-3, 4, 8 and 4/8 ratio) were also examined in same patients. The 17 UTI patients who had Candida species in their urine had a higher HA titer than the other UTI patients without Candida or control subjects, but elderly UTI patients (over 71 years old) did not show higher HA titer. A positive correlation was seen between HA titer and OKT-3, 4 or 4/8 ratio. On the other hand, HA titer and OKT-8 showed a negative relationship. Therefore, the ability to produce the candida antibody might be closely related to the host cellular immune responsiveness.