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DCフィールド | 値 | 言語 |
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dc.contributor.author | 新島, 端夫 | ja |
dc.contributor.author | 阿曽, 佳郎 | ja |
dc.contributor.author | 赤座, 英之 | ja |
dc.contributor.author | 松本, 恵一 | ja |
dc.contributor.author | 河合, 恒雄 | ja |
dc.contributor.author | 橘, 政昭 | ja |
dc.contributor.author | 西尾, 恭規 | ja |
dc.contributor.author | 古武, 敏彦 | ja |
dc.contributor.author | 松村, 陽右 | ja |
dc.contributor.author | 上田, 豊史 | ja |
dc.contributor.author | 高久, 史麿 | ja |
dc.contributor.author | 元吉, 和夫 | ja |
dc.contributor.author | 佐久間, 昭 | ja |
dc.contributor.alternative | NIIJIMA, Tadao | en |
dc.contributor.alternative | ASO, Yosio | en |
dc.contributor.alternative | AKAZA, Hideyuki | en |
dc.contributor.alternative | MATSUMOTO, Keiichi | en |
dc.contributor.alternative | KAWAI, Tsuneo | en |
dc.contributor.alternative | TACHIBANA, Masaaki | en |
dc.contributor.alternative | NISHIO, Yasunori | en |
dc.contributor.alternative | KOTAKE, Toshihiko | en |
dc.contributor.alternative | MATSUMURA, Yosuke | en |
dc.contributor.alternative | UEDA, Toyofumi | en |
dc.contributor.alternative | TAKAKU, Fumimaro | en |
dc.contributor.alternative | MOTOYOSHI, Kazuo | en |
dc.contributor.alternative | SAKUMA, Akira | en |
dc.date.accessioned | 2010-06-02T02:54:43Z | - |
dc.date.available | 2010-06-02T02:54:43Z | - |
dc.date.issued | 1988-08 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/119659 | - |
dc.description.abstract | 尿路性器癌での化学療法剤投与による白血球, 顆粒球減少に対するP-100の抑制および改善効果を検討するため, 多施設二重盲検試験を実施した.1)総実施症例数は261例であり, 効果判定症例は241例, 数値解析症例は240例であった.P-100群, プラセボ群の間において背景因子に偏りはなかった.2)有効度評価において有効以上はP-100群53.0%, プラセボ群38.9%であり, P-100群がプラセボ群に比し有意に優れていた.また, 化学療法開始日より白血球数4, 000/mm3まで回復するのに要した日数はそれぞれ19.6日, 22.6日であり両群間に有意差を認めた.3)副作用はP-100群6例(4.8%), プラセボ群6例(4.4%)に出現し両群間に差はなく, P-100群における副作用の程度は軽症または中等度であり, 投与中止に至ったものは1例のみであった.4)有用度評価においては有用以上がP-100群54.8%, プラセボ群38.1%であり, P-100群がプラセボ群に比し有意に優れていた | ja |
dc.description.abstract | The ability of CSF-HU (P-100) to inhibit and improve the leukocytopenia and granulocytopenia which occur following cancer chemotherapy was investigated in a double-blind study which included an inactive placebo. The drug was administered, 2 vials/day (8 X 10(6)U of P-100), by intravenous drip infusion consecutively for 7 days starting from the 5th day after cancer chemotherapy was initiated. The total cases included in the study numbered 261. The efficacy rate was 53.0% for the P-100 group and 38.9% for the placebo group, while the usefulness rate was 54.8% for the former and 38.1% for the latter. In either case, statistically significant differences were observed in favor of the P-100 group. The reduction in the number of days before the leukocyte count returned to 4, 000/mm3 was statistically significant in the P-100 group. While side effects appeared in both the P-100 (4.8%) and the placebo (4.4%) groups, none of them were considered to be serious. Judging from these results, p-100 was considered to be a useful therapeutic drug for the treatment of leukocytopenia and granulocytopenia following cancer chemotherapy. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | Double blind study | en |
dc.subject | Colony stimulating factor human urine | en |
dc.subject | Granulocytopenia | en |
dc.subject | Leukocytopenia | en |
dc.subject | Cancer chemotherapy | en |
dc.subject.ndc | 494.9 | - |
dc.title | 癌化学療法後の白血球,穎粒球減少症に対するCSF-HU (colony-stimulating factor human urine) の臨床試験成績 - 各種尿路性器癌における二重盲検試験 - | ja |
dc.title.alternative | Clinical study on the effect of CSF-HU (colony stimulating factor human urine) on leukopenia and granulocytopenia induced by cancer chemotherapy--a double-blind study in patients with genito-urinary cancer | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1483 | - |
dc.identifier.epage | 1492 | - |
dc.textversion | publisher | - |
dc.sortkey | 26 | - |
dc.address | 東京大学医学部泌尿器科学教室 | ja |
dc.address | 東京大学医学部泌尿器科学教室 | ja |
dc.address | 東京大学医学部泌尿器科学教室 | ja |
dc.address | 国立横須賀病院泌尿器科 | ja |
dc.address | 癌研究会附属病院泌尿器科 | ja |
dc.address | 慶応義塾大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 大阪府立成人病センター泌尿器科 | ja |
dc.address | 岡山大学医学部泌尿器科学教室 | ja |
dc.address | 九州大学医学部泌尿器科学教室 | ja |
dc.address | 東京大学医学部第三内科学教室 | ja |
dc.address | 自治医科大学造血発生 | ja |
dc.address | 東京医科惚科大学臨床薬理 | ja |
dc.address.alternative | the Department of Urology, University of Tokyo, Faculty of Medicine | en |
dc.address.alternative | the Department of Urology, University of Tokyo, Faculty of Medicine | en |
dc.address.alternative | the Department of Urology, University of Tokyo, Faculty of Medicine | en |
dc.address.alternative | the Department of Urology, Yokosuka National Hospital | en |
dc.address.alternative | the Department of Urology, Japanese Foundationfor Cancer Research, Cancer Institute Hospital | en |
dc.address.alternative | the Department of Urology, School of Medicine Keio University | en |
dc.address.alternative | the Department of Urology, University of Kyoto, Faculty of Medicine | en |
dc.address.alternative | the Department of Urology, The Canterfor Adult Diseases, Osaka | en |
dc.address.alternative | the Department of Urology, Okayama University Medical School, Okayama | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyushu University | en |
dc.address.alternative | the Third Department of Internal Medicine, University of Tokyo, Faculty of Medicine | en |
dc.address.alternative | the Division of Hemopoesis, Institute of Hematology, Jichi Medical School | en |
dc.address.alternative | the Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medicaland Dental University | en |
dc.identifier.pmid | 3057832 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.34 No.8 |
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