小腸転移切除とインターフェロンが奏功した進行性腎細胞癌の1例

Abstract

We report a rare case of advanced renal cell carcinoma which showed complete resolution of multiple metastases following nephrectomy, partial metastatectomy and interferon therapy. A 55-year-old male patient underwent right nephrectomy for the renal cell carcinoma with metastases to the right lung and the left femur. In 45 days from the nephrectomy, metastasis to the right humerus was discovered. Immediately after this, the patient suffered occlusive ileus. Laparotomy revealed multiple intestinal tumors, and a temporary partial jejunotomy was performed for the detectable lesions proved to be metastases later. After this operation the pulmonary lesion revealed regression. Then, the patient was treated with daily intramuscular administration of human lymphoblastic interferon (3 X 10(6) units). In consequence, the pulmonary lesion showed complete resolution in two months and the humeral lesion in five months. The left femur which remained osteolytic was replaced by an artificial bone, and revealed no cancer cells histologically. No evidence of metastatic lesion has been found with following intestinal examinations. More than a year has passed since the detection of disease and complete response has persisted for three months under the interferon therapy.