慢性前立腺炎患者におけるエノキサシンの前立腺液移行について

Abstract

慢性前立腺炎患者の血清中および前立腺液中のエノキサシン(ENX)濃度を測定した.血清濃度は平均1.24 μg/ml, 前立腺液内濃度は平均0.69 μg/ml, 対血清比は平均0.58と高い値を示した.今回求められた前立腺液濃度は代表的グラム陰性桿菌である大腸菌や変形菌のENXの80%最小発育阻止濃度を上回る結果である

To examine the diffusion of enoxacin into the prostatic fluid of patients with chronic prostatitis, the serum level and the expressed prostatic secretion (EPS) level of enoxacin were measured. Enoxacin was administered orally at a dose of 200 mg in 24 chronic prostatitis patients. One hour later, blood and EPS samples were taken. The level of enoxacin was measured by the bioassay using E. coli (Kp strain). In 24 patients, the mean value of enoxacin was 1.24 micrograms/ml in the serum and 0.69 micrograms/ml in the EPS. The mean ratio of EPS/serum was 0.58. These results indicated that enoxacin diffused well into the prostatic fluid of chronic prostatitis patients.