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34_1911.pdf | 346.04 kB | Adobe PDF | 見る/開く |
タイトル: | 前立腺癌および睾丸腫瘍の化学療法 - より有効な治療法を目指したin vitroおよびin vivo実験での検討 - |
その他のタイトル: | Chemotherapy of carcinoma of the prostate and testis: experimental study in vivo and in vitro |
著者: | 岡田, 謙一郎 金丸, 洋史 吉貴, 達寛 橋村, 孝幸 西村, 一男 飛田, 収一 西尾, 恭規 大石, 賢二 吉田, 修 山内, 民男 |
著者名の別形: | OKADA, Kenichiro KANAMARU, Hiroshi YOSHIKI, Tatsuhiro HASHIMURA, Takayuki NISHIMURA, Kazuo HIDA, Shuichi NISHIO, Yasunori OISHI, Kenji YOSHIDA, Osamu YAMAUCHI, Tamio |
キーワード: | Prostate cancer Testicular tumor Chemotherapy HTCA Nude mouse |
発行日: | Nov-1988 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 34 |
号: | 11 |
開始ページ: | 1911 |
終了ページ: | 1916 |
抄録: | Prostate cancer: Considering the stagnation in chemotherapy of prostate cancer in recent years, the following experiments were carried out to determine their clinical value. Surgical specimens from 6 patients, 2 permanent cell lines (EB 33 and PC 93) originated from human prostate cancer and a tumor line serially transplanted in nude mice (PC-NCC) were subjected to chemosensitivity tests such as human tumor cloning assay (HTCA) and/or in vivo tumor growth curve experiments using nude mice. The possible chemosensitive drugs screened by using surgical specimens and PC-NCC tumor were cisplatinum (CDDP), bleomycin (BLM), 5-FU, vincristine (VCR), adriamycin (ADM) and methotrexate (MTX). Most of these drugs were also judged as "effective" by HTCA using a permanent cell line. The minimal discrepancy among them may lead to the conclusion that an in vitro assay using a cell line can substitute for the assay using surgical specimens which can not be obtained frequently. Partly based on the data obtained a chemotherapy regimen, VPM-CisCF, consisting of VCR, peplomycin, MTX, CDDP, cytosine arabinoside (Ara-C) and 5-FU, was designed. The effectiveness of this regimen was demonstrated experimentally. Testis cancer: Two different lines of experiments were performed. A human testicular cancer serially transplanted in nude mice was repeatedly exposed to CDDP in vivo to obtain hyposensitivity to this drug. The synergistic effect of CDDP and VP-16 was demonstrated in the tumor thus obtained. One of its mechanisms has been suggested by partial accumulation of cancer cells in the G1-S and G2-M phase in which CDDP exerts its potential effect.(ABSTRACT TRUNCATED AT 250 WORDS) |
URI: | http://hdl.handle.net/2433/119780 |
PubMed ID: | 2468265 |
出現コレクション: | Vol.34 No.11 |
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