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ファイル | 記述 | サイズ | フォーマット | |
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34_1903.pdf | 3.31 MB | Adobe PDF | 見る/開く |
タイトル: | ヌードマウス移植ヒト睾丸腫瘍を用いた抗癌剤感受性試験と臨床成績 |
その他のタイトル: | Anti-cancer drug sensitivity test against human testicular cancer xenograft--comparison with clinical results of chemotherapy |
著者: | 三木, 恒治 古武, 敏彦 |
著者名の別形: | Miki, Tsuneharu Kotake, Toshihiko |
キーワード: | Testicular cancer Nude mice Chemotherapy |
発行日: | Nov-1988 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 34 |
号: | 11 |
開始ページ: | 1903 |
終了ページ: | 1909 |
抄録: | The antitumor effect of vinblastine (VBL), vincristine (VCR), etoposide (VP-16), teniposide (VM-26), cisplatin (CDDP), CBDCA (JM-8, Carboplatin), CHIP (JM-9), DWA2114R and recombinant human tumor necrosis factor (TNF) on four human testicular cancers heterotransplanted in nude mice were studied. The treatments with CDDP, CBDCA or CHIP significantly reduced the transplanted tumors. Combination chemotherapy with CDDP, bleomycin and VBL or VCR or VP-16 or VM-26 also revealed significant tumor regression. The antitumor effect of TNF on human testicular xenografts was much more evident when it was given intratumorally than when given intravenously. Teratoma was resistant to TNF even when it was administered intratumorally. Those results are briefly discussed and compared with the clinical results of chemotherapy. Several problems in anticancer drug sensitivity test against human tumor xenografts are also discussed. |
URI: | http://hdl.handle.net/2433/119781 |
PubMed ID: | 3242364 |
出現コレクション: | Vol.34 No.11 |
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