泌尿器科領域におけるポリミキシンBの局所投与療法について

Abstract

1) The yearly prevalence rate of pyocyaneus bacilli isolated at the Department of Urology of Hiroshima University Hospital was below 10% with the peak rate 11.8% in 1962 and 1965. No trend of recent increase was found. 2) The frequency of sensitive strain of pyocyaneus bacilli against PL-B in 1966 and 1967 was 92.2% and 83.3%, respectively, which was rather highly sensitive. 3) Local administration of PL-B was attempted in 21 patients including 9 cases of cyanomycosis following prostatectomy and 12 cases of postoperative intractable fistula with pyocyaneus infection. In 16 out of 21 cases (76.2%) treated, the therapy was found to be effective as the bacilli disappeared in them. 4) Effectiveness of the treatment as evaluated by duration of therapy necessitated was compared between the patients given local administration of PL-B solution and the control group treated with local irrigation with 0.1% Rivanol solution and 0.01% oxycyan solution consisting of 10 post prostatectomy patients with usual course and 6 patients with intractable postoperative cyanomycosis. A definite shortening of duration of the therapy was evident in the study group than in the control. 5) No noticeable side effect was encountered in all cases treated.