思春期男子の内分泌動態

Abstract

Endocrinological investigations were carried out in 50 cases of healthy male adolescent to analyze the data by age. In 8 subjects the study was further continued for successive 4 years in order to observe the changes by progress of age. The results are summarized as follows. 1) The endocrinological status of male adolescent was characterized by wide variation by individuals as seen in somatic growth. 2) The urinary excretion of 17-KS and gonadotropin showed an invariable increase with progress of age. However, there was a great individual variation on the time of sudden increase. 3) All of urinary 17-KS fractions also rose with increase of age with an exception of the VII fraction. In particular, the increase of the IV and V fractions, which are supposed to originate from the gonad, was so striking that the ratio of IV + V/III+ VI+ VII became greater in accordance with the ageing. 4) Urinary excretion of 17-0HCS had shown nearly normal adult values in many subjects during the first half period of adolescence, and no distinct increase as seen in 17-KS or urinary gonadotropin was demonstrated during adolescence. 5) Urinary estrogen value showed a sudden transient increase during a certain period of adolescence with a subsequent decrease in a few subjects. 6) There was a definite correlation between the increases of urinary 17-KS and urinary gonadotropin and the rate of somatic growth especially increase of the height.