泌尿器科領域における静注用クロタオンの治験

Abstract

"Chlotaon", each vial containing 333 mg of chloramphenicol and 167 mg oleandomycin, was administered intravenously to 28 operated patients for prophylaxis of postoperative infection and to 11 patients with urinary tract infection. The inhibition of postoperative infection was achieved in 25 out of 28 patients (89.3%). In cases of urinary tract infection, definite improvement of symptoms and urinary findings were observed in 10 out of 20 patients (50%), including 9 operative cases who had urinary tract infection preoperatively. The less effectiveness of the drug in this group of urinary tract infection might be due to the fact that a half of bacteria had resistance to these antibiotics. However, our clinical experience indicated that a better effectiveness is presented when this antibiotic is used according to the results of sensitivity test. Based on these results, it is supposed that "Chlotaon" of intravenous use is one of the excellent antibiotics in urologic practice. No noticeable side effect was encountered in all patients administered.