男性不妊患者に対するATP,Citrulline,Aspartic Acid投与の影響

Abstract

Sixty-five cases of male infertility were treated by administration of ATP, citrulline, and aspartic acid, either alone or in combination. 1) Out of 22 cases to which 500 mg of citrulline was administered per day, 11 showed remarkable increase of sperm count and 5 showed improvement of sperm motility. Five couples succeeded in pregnancy in this group. 2) Continuous administration of aspartic acid, 450 mg daily, resulted in decrease of both sperm count and motility. 3) Administration of ATP, 120 mg daily, produced remarkable increase of sperm count in 9 of 17, and improvement of sperm motility in 4 of 17. One succeeded in pregnancy. 4) To seven cases in which ATP alone gave unsatisfactory result, both aspartic acid (450 mg per day) and ATP (120 mg per day) were administered. Obvious increase of sperm count was observed in 4 of 7. 5) To the group in which ATP or citrulline were not effective, both of them were administered in combination; and sperm count increased in 4 of 7. From above results, it was speculated that some of the compounds related to the ornithine cycle were of significance in spermatogenesis.