泌尿器腫瘍と酵素 4.Dimethylnitrosamineによる実験的腎腫瘍における Lactic Dehydrogenase，Alkaline Phosphatase，Leucine Aminopeptidase，Total Acid Phosphatase 活性およびLDH isozymesの変動について

Abstract

In order to induce renal tumors, Wistar strain rats were given special food containing 500 ppm of dimsthylnitrosamins for 2 wesks. Renal and serum activities of lactic dehydrogenase (LDH), alkaline phosphatase (AlP), leucine aminopeptidase (LAP), total acid phosphatase (TAP) and LDH isozymes were determined successively. The results are summarized as follows. 1. Both of serum and renal LDH activities markedly increased after the 7th month of the experimental period. At the same time the LDH isozymes pattern showed increases of M type and the fraction III with a decrease of H type. 2. Both of serum and renal AQP activities slightly decreased during the latter half of the experimental period. 3. LAP activity slightly decreased in the kidney and increased in serum along with the elapse of time. 4. TAP activity showed no definite trend both in the kidney and in serum.