腎摘除後の電解質代謝に関する実験的研究 第III編 両腎摘除後の遊離小腸管における電解質の態度

Abstract

1) Uremic dogs were made and their isolated small intestines were intermittently perfused. Not only serum electrolytes, urea nitrogen and total protein but potassium, phosphorus, urea nitrogen and total protein in the irrigated fluid were determined. Removal of urea nitrogen was achieved to some extent, but the electrolytes unbalance was not corrected although hyperpotassemia was slightly reduced. 2) Movement of sodium and potassium across the intestinal mucosa of the uremic dogs was investigated with use of radioisotope technique. In normal condition, namely non-uremic, there was only absorption and almost no excretion of sodium through intestinal mucosa. Potassium movement was unremarkable. In uremic state, sodium absorption from the intestinal mucosa decreased and its excretion increased with gradually elevating excretion/absorption ratio by hours, reaching 2/1 at two hours. Active potassium transport was also observed across the mucosa, and the maximum excretion/absorption ratio was observed at thirty minutes of perfusion. 3) The effect of aldosterone on the sodium and potassium excretion into the intestine was investigated with radioisotope method. In uremic dogs, aldosterone inhibited excretion of sodium and promoted that of potassium.